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Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R01 Clinical Trial Optional)

National Institutes of Health
Currently Open As of Jan 11, 2026
Application Opens Nov 22, 2024
Deadline Jan 7, 2028
Geography Not specified
Eligible Applicants
Public and State controlled institutions of higher educationNative American tribal governments (Federally recognized)Private institutions of higher educationPublic housing authorities/Indian housing authoritiesNonprofits having a 501(c)(3) status with the IRS, other than institutions of higher educationNative American tribal organizations (other than Federally recognized tribal governments)Others (see text field entitled "Additional Information on Eligibility" for clarification)City or township governmentsState governmentsNonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher educationCounty governmentsIndependent school districtsSpecial district governmentsFor profit organizations other than small businessesSmall businesses

Overview

The purpose of this Notice of Funding Opportunity (NOFO) is to encourage applications to pursue invasive neural recording studies focused on mental health-relevant questions. Invasive neural recordings provide an unparalleled window into the human brain to explore the neural circuitry and neural dynamics underlying complex moods, emotions, cognitive functions, and behaviors with high spatial and temporal resolution. Additionally, the ability to stimulate, via the same electrodes, allows for direct causal tests by modulating network dynamics. This funding opportunity aims to target a gap in the scientific knowledge of neural circuit function related to mental health disorders. Researchers should target specific questions suited to invasive recording modalities that have high translational potential. Development of new technologies and therapies are outside the scope of this NOFO.

Eligibility Requirements

  • Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Contact Information

Contact: National Institutes of Health

Email:

Phone: 301-402-2541

Next Steps

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Data Source & Verification

Source: www.grants.gov
Last Verified: Jan 11, 2026, 1:38 AM
Important: Always verify current details directly on the official grant website before applying.