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Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)
National Institutes of Health
Currently Open
As of Jan 8, 2026
Eligible Applicants
Special district governmentsFor profit organizations other than small businessesPublic and State controlled institutions of higher educationIndependent school districtsState governmentsNonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher educationCounty governmentsNative American tribal organizations (other than Federally recognized tribal governments)Small businessesPublic housing authorities/Indian housing authoritiesNonprofits having a 501(c)(3) status with the IRS, other than institutions of higher educationCity or township governmentsNative American tribal governments (Federally recognized)Private institutions of higher educationOthers (see text field entitled "Additional Information on Eligibility" for clarification)
Overview
The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to elucidate a role for understudied proteins in rare disease. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s). A list of eligible proteins is provided and are members of druggable protein families that have a known association with a rare disease. This NOFO is intended to jumpstart research on understudied proteins that are associated with rare diseases and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins within the context of rare disease.
Funding Information
Eligibility Requirements
- Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Source: www.grants.gov
Last Verified: Jan 8, 2026, 5:28 PM
Important: Always verify current details directly on the official grant website before applying.