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Effectiveness Trials to Test Mental Health System Interventions (R61/R33 Clinical Trial Required)

National Institutes of Health
Currently Open As of Jan 8, 2026
Application Opens Nov 26, 2024
Deadline Oct 15, 2027
Geography Not specified
Eligible Applicants
Public and State controlled institutions of higher educationNative American tribal organizations (other than Federally recognized tribal governments)Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher educationSmall businessesSpecial district governmentsPublic housing authorities/Indian housing authoritiesOthers (see text field entitled "Additional Information on Eligibility" for clarification)Private institutions of higher educationState governmentsNonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher educationFor profit organizations other than small businessesIndependent school districtsCounty governmentsNative American tribal governments (Federally recognized)City or township governments

Overview

This R61/R33 concept complements NIMHs suite of clinical trial NOFOs by supporting feasibility and infrastructure development (R61) followed by well-powered clinical trials (R33) to test the effectiveness of system interventions and strategies for improving the organization, delivery, coordination, and clinical and functional outcomes of mental health services. System interventions - which may span, for example, structural, policy, organizational, and interpersonal domains - attend to issues about the access, equity, engagement/utilization, value (cost/financing), management, or quality and safety of mental health services, with the goal of improved care processes and clinical and functional outcomes. Accordingly, the focus of system interventions may include a variety of care settings, such as health systems and organizations, mental health and community clinics, schools, and child welfare or juvenile justice systems

Eligibility Requirements

  • Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Contact Information

Contact: National Institutes of Health

Email:

Phone: 301-402-2541

Next Steps

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Data Source & Verification

Source: www.grants.gov
Last Verified: Jan 8, 2026, 5:28 PM
Important: Always verify current details directly on the official grant website before applying.